Comparative Study of Alterations in Tri-iodothyronine (T3) and Thyroxine (T4) Hormone Levels in Breast and Ovarian Cancer
نویسندگان
چکیده
Objective : The present study was designed to investigate variations in the levels of thyroid hormones (T3, T4) in breast and ovarian cancers patients. Methods : A total 120 subjects were recruited (without thyroid history) divided into three groups; A, B and C. Group A as control with healthy individuals. While group B and group C were consisting of breast cancer and ovarian cancer patient respectively. Blood samples (5 ml) were taken and analyzed to estimate the levels of serum T3 (tri-iodothyronine) and T4 (thyroxin) hormones. R esults : Statistically significant difference (P=0.000* and P=0.017*) was obtained among all groups. A significant increase in T3 (P=0.000*) and T4 (0.005*) levels was observed among breast cancer patients as compared to healthy controls. While for ovarian cancer patients conflicting results were found for T3 and T4 levels in the serum i.e. insignificant difference was found in T3 (P=0.209) and T4 (P=0.050) as compared to control. Our results showed that in the breast cancer and ovarian cancer patients the thyroid hormone (T3 and T4) level has been altered from the normal ranges as compared to the normal healthy individuals. Conclusion : We conclude that hyperthyroidism has profound effects on breast cancer and ovarian cancer cells proliferation.
منابع مشابه
Effect of Thyroid Hormone Levels on Glycemic Control: The Indian Context
Objective: Diabetes mellitus (DM) is known as the silent pandemic. It is hypothesized that other endocrine systems are affected by the metabolic changes occurring due to DM. We aimed to investigate the correlation of thyroid hormones with glycaemic and lipid parameters. Materials and Methods: 81 diabetic patients and 81 non-diabetic age and sex-matched healthy volunteers participated in the st...
متن کاملComparison of serum levels of Tri‐iodothyronine (T3), Thyroxine (T4), and Thyroid‐Stimulating Hormone (TSH) in preeclampsia and normal pregnancy
BACKGROUND The physiological changes in thyroid gland during pregnancy have been suggested as one of the pathophysiologic causes of preeclampsia. OBJECTIVE The aim of this study was comparison of serum levels of Tri-iodothyronine (T3), Thyroxine (T4), and Thyroid-Stimulating Hormone (TSH) in preeclampsia and normal pregnancy. MATERIALS AND METHODS In this case-control study, 40 normal pregn...
متن کاملThe Effect of Different Levels of Rapeseed Meal with and without Enzyme on the Performance and the Serum Level of Triiodothyronine (T3), Thyroxine (T4) and Thyroid Stimulating Hormone (TSH) in Broiler Chickens
In order to investigate the effect of different levels of rapeseed meal on performance and content of triiodothyronine (T3), thyroxine (T4) and thyroid stimulating hormone (TSH) in broiler chickens’ blood, 640 1-d-old Ross male broiler chickens were studied through a 4 × 2 factorial arrangement including 4 levels of rapeseed meal (RSM) (0, 5, 10 and 15 percent) and two levels of enzyme (0 and 0...
متن کاملCalculation of Thyroid Dose with Planner System and Evaluation of Thyroid Function after Radiotherapy for Patients with Breast Cancer
Background: Much research has widely been conducted into thyroid hormones levels following radiotherapy for breast cancer. Consequently, in this study, we evaluated to relate the rate of thyroid hormones levels with the dose distribution among breast cancer patients.Material and Methods: Thirty patients were treated with 4-field breast cancer radiotherapy. The dose volume histograms, the volume...
متن کاملMaternal thyroxine and 3,5,3'-tri-iodothyronine kinetics in near-term pregnant rats at two different levels of hypothyroidism.
Thyroid hormones are extremely important for development of the fetal central nervous system. Thyroidectomy results in severe hypothyroidism. In this study two levels of maternal hypothyroidism were reached by administration of different amounts of thyroxine (T4) and 3,5,3'-tri-iodothyronine (T3) to thyroidectomized pregnant rats. We examined the production, distribution and transport of T4 and...
متن کامل